Lupus Anticoagulunt Associated with Transient Severe Factor X Deficiency: A Report of Two Patients Presenting with Major Bleeding Complications

Authors

Aneel A. Ashrani, University of Minnesota - Twin Cities
Agnes Aysola, University of Minnesota - Twin Cities
Hani Al-Khatib MD, St. Cloud Hospital, CentraCare Health
William L. Nichols, Mayo Clinic, Rochester

Document Type

Article

Publication Date

2003

Abstract

Abstract

Acquired factor X (FX) deficiency is rare, but has been reported in diverse disease states, including systemic amyloidosis and respiratory infections. FX deficiency associated with lupus anticoagulant (LA) and a bleeding diathesis has not been previously reported. We report two patients both of whom presented with a severe bleeding diathesis after a preceding respiratory infection due to isolated FX deficiency associated with a LA. The FX deficiency and LA were transient. We conclude that patients with LA may rarely present with severe acquired FX deficiency. This may be another mechanism whereby patients with antiphospholipid antibodies present with bleeding complications.

Recommended Citation

Ashrani, Aneel A.; Aysola, Agnes; Al-Khatib, Hani MD; and Nichols, William L., "Lupus Anticoagulunt Associated with Transient Severe Factor X Deficiency: A Report of Two Patients Presenting with Major Bleeding Complications" (2003). Articles. 35.
https://digitalcommons.centracare.com/articles/35